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      Chromatin modifications and their function.

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      Cell
      Elsevier BV

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          Abstract

          The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Feb 23 2007
          : 128
          : 4
          Affiliations
          [1 ] The Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB21QN, UK. t.kouzarides@gurdon.cam.ac.uk
          Article
          S0092-8674(07)00184-5
          10.1016/j.cell.2007.02.005
          17320507
          46c65441-e17c-4d63-aadc-8c9eb61b28c1
          History

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