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      Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone.

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          Abstract

          One third of asthmatic women report a decreased expiratory peak flow during menses. Since asthma is characterized by lung inflammation and bronchopulmonary hyperresponsiveness, we investigated the role played by estradiol in allergic lung inflammation.

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          The effect of the menstrual cycle on asthma presentations in the emergency department.

          B Eskin, W H Spivey, William R. Silverman … (1996)
          Seventy-five percent of all adult hospital admissions for asthma are women. To determine whether a relationship exists between phases of the menstrual cycle and asthma exacerbations in adult females. Data were analyzed from 182 nonpregnant, adult females with asthma aged 13 years to menopause. Date of presentation, patient age, duration of asthma attack, date of last menstrual period, regular interval between menses, presenting peak expiratory flow rate, and admission and discharge decision were recorded prospectively. Treatment interventions abstracted retrospectively from patient charts included use of oxygen, xanthines, beta-adrenergic agonists, corticosteroids, and magnesium sulfate. The menstrual cycle was divided into 4 phases based on fluctuations in serum estradiol levels. The 4 intervals were preovulatory (days 5-11), periovulatory (days 12-18), postovulatory (days 19-25), and perimenstrual (days 26-4). Data were analyzed with a goodness-of-fit chi 2. Between June 1991 and May 1992, 182 females (mean +/- SD age, 28.5 +/- 8.0 years) were surveyed. No significant differences were noted for use of oxygen, beta-adrenergic agonists, xanthines, or magnesium among members of the 4 menstrual groups. Intervention with corticosteroids was least in the postovulatory interval (y:n) 0.5:1 and greatest in the preovulatory interval 3.0:1 (alpha = .03) Presentations by menstrual interval were as follows: preovulatory, 36 (20%); periovulatory, 43 (24%); postovulatory, 18 (10%); and perimenstrual, 85 (46%) (alpha < .01). Asthma presentations are least frequent when serum estradiol levels are at a sustained peak. We observed a 4-fold variation in asthma presentations during the perimenstrual interval, when serum estradiol levels decrease sharply after that prolonged peak. These findings suggest that monthly variations in serum estradiol levels may influence the severity of asthma in adult females.
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            Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization.

            Nathan D. Wong, I Mota (1969)
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              Melatonin modulates allergic lung inflammation.

              Wilfried De Neve, Miguel Menezes de Sequeira, Delio Martins … (2001)
              Asthma is an inflammatory lung disease characterized by cell migration, bronchoconstriction and hyperresponsiveness, and can be induced, as an experimental model, by ovalbumin sensitization followed by a challenge. In addition to the well-known immunostimulatory effects of melatonin, research has identified some of its anti-inflammatory properties. In this study, we evaluated the influence of pinealectomy and melatonin administration on cell migration in an experimental model of allergic airway inflammation. We evaluated, in pinealectomized rats treated or not with melatonin, cell migration into the bronchoalveolar fluid, the number of cells and their proliferative activity in the bone marrow, and plasma corticosterone levels. Pinealectomy reduces, 24 hr after the challenge, the total cell number count in the lung and bone marrow cell proliferation, without changing the number of cells in the bone marrow or in the peripheral blood. This fact suggests that melatonin is important in the control of cell recruitment from the bone marrow and the migration of those cells to the lung. Melatonin administration to pinealectomized rats seems to restore the ability of cells to migrate from the bone marrow to the bronchoalveolar fluid. So, the development of specific inhibitors of melatonin would benefit patients with asthma.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Neuroimmunomodulation
                Title: Neuroimmunomodulation
                Publisher: S. Karger AG
                ISSN: 1021-7401
                ISSN (Print): 1021-7401
                Publication date (Electronic): 2004
                Volume: 11
                Issue: 1
                Affiliations
                [1 ] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
                Article
                Publisher Item ID: 72965
                DOI: 10.1159/000072965
                PubMed ID: 14557675
                SO-VID: f4ae664a-6cea-4b0f-be0a-71c8428aaacb
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