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      The cell biology of neurogenesis

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      Nature Reviews Molecular Cell Biology
      Springer Nature

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          Abstract

          During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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          Author and article information

          Journal
          Nature Reviews Molecular Cell Biology
          Nat Rev Mol Cell Biol
          Springer Nature
          1471-0072
          1471-0080
          October 2005
          October 2005
          : 6
          : 10
          : 777-788
          Article
          10.1038/nrm1739
          60cbaef2-aa55-4e1a-9653-997a0c125701
          © 2005
          History

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