Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral  Clavularia viridis

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Abstract

In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B ( 1), and A ( 2), along with three known sesquiterpenes ( 3–5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.

Author and article information

Journal

Journal ID (publisher-id): CJNM

Title: Chinese Journal of Natural Medicines

Publisher: Elsevier

ISSN (Electronic): 1875-5364

Publication date (Electronic): 20 November 2017

Volume: 15

Issue: 11

Pages: 855-859

Affiliations

[1] ¹College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China

[2] ²Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China

[3] ³State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Author notes

*Corresponding author: WANG De-Cai, E-mail: dcwang@ 123456njtech.edu.cn ; GUO Yue-Wei, Tel/Fax: 86-21-50807088, E-mail: ywguo@ 123456simm.ac.cn

These authors have no conflict of interest to declare.

Article

Publisher ID: S1875-5364(18)30019-0

DOI: 10.1016/S1875-5364(18)30019-0

SO-VID: 7aa190d8-ed62-4ecb-a21c-dc91835cecc8

History

Date received : 08 April 2017

Funding

Funded by: Natural Science Foundation of China

Award ID: 81520108028

Award ID: 21672230

Award ID: 41506187

Award ID: 816013016

Funded by: SKLDR/SIMM Project

Award ID: SIMM1501ZZ-03

This work was supported by the Natural Science Foundation of China (Nos. 81520108028, 21672230, 41506187, and 816013016) and the SKLDR/SIMM Project (No. SIMM1501ZZ-03).

ScienceOpen disciplines: Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine

Keywords: Cytotoxic activity,Trinor-guaiane sesquiterpene, Clavularia viridis ,Soft coral

Data availability:

ScienceOpen disciplines: Medicine, Pharmaceutical chemistry, Pharmacology & Pharmaceutical medicine, Complementary & Alternative medicine

Keywords: Cytotoxic activity, Trinor-guaiane sesquiterpene, Clavularia viridis , Soft coral