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      Roles of integrin in tumor development and the target inhibitors.

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          Abstract

          Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.

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          Author and article information

          Journal
          Chin J Nat Med
          Chinese journal of natural medicines
          Elsevier BV
          1875-5364
          1875-5364
          Apr 2019
          : 17
          : 4
          Affiliations
          [1 ] State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.
          [2 ] State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zhaoli@cpu.edu.cn.
          Article
          S1875-5364(19)30028-7
          10.1016/S1875-5364(19)30028-7
          31076128

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