13
views
0
recommends
+1 Recommend
1 collections
    0
    shares

      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

      Submit here before July 31, 2024

      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

      • Record: found
      • Abstract: found
      • Article: found

      Osteopontin and calcium stone formation.

      Nephron. Physiology
      Animals, Calcium Oxalate, metabolism, Humans, Kidney Calculi, Osteopontin, Sialoglycoproteins

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Osteopontin (OPN) is a phosphorylated protein of wide tissue distribution that is found in association with dystrophic calcification including in the organic matrix of kidney stones. It is a strong inhibitor of crystal formation and growth in vitro, but there is still debate regarding its effects upon crystal adhesion to tubular epithelial cells. In this brief review, we will outline the evidence implicating OPN in stone disease with the primary emphasis being on the interaction of OPN with calcium oxalate (CaOx), the major constituent of calcium containing stones. Finally, preliminary data is presented regarding the amounts and features of OPN present in the urine of stone formers and normal individuals. Copyright (c) 2004 S. Karger AG, Basel.

          Related collections

          Most cited references33

          • Record: found
          • Abstract: not found
          • Article: not found

          Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin.

            Bone sialoprotein (BSP) and osteopontin (OPN) are two members of the SIBLING (Small Integrin-Binding LIgand, N-linked Glycoprotein) family of genetically related proteins that are clustered on human chromosome 4. We present evidence that this entire family is the result of duplication and subsequent divergent evolution of a single ancient gene. The solution structures of these two post-translationally modified recombinant proteins were solved by one dimensional proton NMR and transverse relaxation times. The polypeptide backbones of both free BSP and OPN rapidly sample an ensemble of conformations consistent with them both being completely unstructured in solution. This flexibility appears to enable these relatively small glycoproteins to rapidly associate with a number of different binding partners including other proteins as well as the mineral phase of bones and teeth. These proteins often function by bridging two proteins of fixed structures into a biologically active complex. Copyright 2001 Academic Press.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Osteopontin--a molecule for all seasons

              M Mazzali (2002)
                Bookmark

                Author and article information

                Journal
                15499214
                10.1159/000080263

                Chemistry
                Animals,Calcium Oxalate,metabolism,Humans,Kidney Calculi,Osteopontin,Sialoglycoproteins
                Chemistry
                Animals, Calcium Oxalate, metabolism, Humans, Kidney Calculi, Osteopontin, Sialoglycoproteins

                Comments

                Comment on this article