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      Augmented Renal Clearance in Critically Ill Patients: A Systematic Review.

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          Abstract

          Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context. Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resulting in subtherapeutic concentrations and poorer clinical outcomes when standard dosage guidelines are followed.

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          Author and article information

          Journal
          Clin Pharmacokinet
          Clinical pharmacokinetics
          Springer Science and Business Media LLC
          1179-1926
          0312-5963
          September 2018
          : 57
          : 9
          Affiliations
          [1 ] Department of Pharmacy, Cruces University Hospital, Plaza de Cruces 12, 48903, Barakaldo, Bizkaia, Spain.
          [2 ] Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Lascaray Research Center, University of the Basque Country UPV/EHU, Paseo de la Universidad, 7, 01006, Vitoria-Gasteiz, Spain.
          [3 ] Intensive Care Unit, University Hospital of Alava, c/ Olaguibel no 29, Vitoria-Gasteiz, Spain.
          [4 ] Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Lascaray Research Center, University of the Basque Country UPV/EHU, Paseo de la Universidad, 7, 01006, Vitoria-Gasteiz, Spain. arantxa.isla@ehu.eus.
          [5 ] Pharmacokinetic, Nanotechnology and Gene Therapy Group (PharmaNanoGene), Faculty of Pharmacy, Lascaray Research Center, University of the Basque Country UPV/EHU, Paseo de la Universidad, 7, 01006, Vitoria-Gasteiz, Spain. marian.solinis@ehu.eus.
          Article
          10.1007/s40262-018-0636-7
          10.1007/s40262-018-0636-7
          29441476
          b19efa73-d587-49de-970f-a08813b01fc6
          History

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