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      International Journal of Nanomedicine (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the application of nanotechnology in diagnostics, therapeutics, and drug delivery systems throughout the biomedical field. Sign up for email alerts here.

      105,621 Monthly downloads/views I 7.033 Impact Factor I 10.9 CiteScore I 1.22 Source Normalized Impact per Paper (SNIP) I 1.032 Scimago Journal & Country Rank (SJR)

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      Functional consequences for primary human alveolar macrophages following treatment with long, but not short, multiwalled carbon nanotubes.

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          Abstract

          Multiwalled carbon nanotubes (MWCNTs) are a potential human health hazard, primarily via inhalation. In the lung, alveolar macrophages (AMs) provide the first line of immune cellular defense against inhaled materials. We hypothesized that, 1 and 5 days after treating AMs with short (0.6 μm in length; MWCNT-0.6 μm) and long (20 μm in length; MWCNT-20 μm) MWCNTs for 24 hours, AMs would exhibit increased markers of adverse bioreactivity (cytokine release and reactive oxygen species generation) while also having a modified functional ability (phagocytosis and migration).

          Most cited references42

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          Carbon nanotubes: present and future commercial applications.

          Michael F. L. De Volder, Sameh H Tawfick, Ray Baughman … (2013)
          Worldwide commercial interest in carbon nanotubes (CNTs) is reflected in a production capacity that presently exceeds several thousand tons per year. Currently, bulk CNT powders are incorporated in diverse commercial products ranging from rechargeable batteries, automotive parts, and sporting goods to boat hulls and water filters. Advances in CNT synthesis, purification, and chemical modification are enabling integration of CNTs in thin-film electronics and large-area coatings. Although not yet providing compelling mechanical strength or electrical or thermal conductivities for many applications, CNT yarns and sheets already have promising performance for applications including supercapacitors, actuators, and lightweight electromagnetic shields.
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            Macrophage receptors and immune recognition.

            P R Taylor, L. Martinez-Pomares, M Stacey … (2005)
            Macrophages express a broad range of plasma membrane receptors that mediate their interactions with natural and altered-self components of the host as well as a range of microorganisms. Recognition is followed by surface changes, uptake, signaling, and altered gene expression, contributing to homeostasis, host defense, innate effector mechanisms, and the induction of acquired immunity. This review covers recent studies of selected families of structurally defined molecules, studies that have improved understanding of ligand discrimination in the absence of opsonins and differential responses by macrophages and related myeloid cells.
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              Essential involvement of interleukin-8 (IL-8) in acute inflammation.

              A. Harada, N Sekido, T Akahoshi … (1994)
              Neutrophil infiltration into inflammatory sites is one of the hallmarks of acute inflammation. Locally produced chemotactic factors are presumed to mediate the sequence of events leading to the infiltration at inflammatory sites. Interleukin-8 (IL-8), a novel leukocyte chemotactic activating cytokine (chemokine), is produced by various types of cells upon stimulation with inflammatory stimuli and exerts a variety of functions on leukocytes, particularly, neutrophils in vitro. However, no definitive evidence has been presented on its role in recruiting and activating neutrophils in the lesions of various types of inflammatory reactions. We administered a highly specific neutralizing antibody against IL-8 in several types of acute inflammatory reactions, including lipopolysaccharide (LPS)-induced dermatitis, LPS/IL-1-induced arthritis, lung reperfusion injury, and acute immune complex-type glomerulonephritis. Anti-IL-8 treatment prevented neutrophil-dependent tissue damage as well as neutrophil infiltration in these conditions. These results suggest that IL-8 plays a causative role in acute inflammation by recruiting and activating neutrophils.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Int J Nanomedicine
                Title: International journal of nanomedicine
                Publisher: Informa UK Limited
                ISSN (Electronic): 1178-2013
                ISSN (Print): 1176-9114
                Publication date (Electronic): 2015
                Volume: 10
                Affiliations
                [1 ] Lung Cell Biology, Section of Pharmacology and Toxicology, National Heart and Lung Institute, Imperial College London, London, UK.
                Article
                Publisher Item ID: ijn-10-3115
                DOI: 10.2147/IJN.S77867
                PMC ID: 4412488
                PubMed ID: 25960651
                SO-VID: 0ab2f88d-35f2-40e7-82d8-04f4a29518a0
                History

                Keywords: MWCNTs,alveolar macrophages,bioreactivity,cytokines,nanotechnology,phagocytosis
                Data availability:
                Keywords: MWCNTs, alveolar macrophages, bioreactivity, cytokines, nanotechnology, phagocytosis

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