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Abstract
Pharmaceutical research has focused on the discovery and development of anticancer
drugs. Clinical application of chemotherapy drugs is limited due to their severe side
effects. In this regard, new naturally occurring anticancer drugs have gained increasing
attention because of their potential effectiveness and safety. Fruits and vegetables
are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus
of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical
and pharmacological studies show that carbazole alkaloids and coumarins from Clausena
plants exhibit anticancer activity. This review summarizes research progresses made
in the anticancer properties of plants belonging to Clausena ; in particular, compounds
with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation
effects are discussed. This review reveals the potential use of plants from Clausena
in preventing and treating cancer and provides a basis for development of relevant
therapeutic agents.
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines