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      Effect of chronic heart rate reduction with ivabradine on carotid and aortic structure and function in normotensive and hypertensive rats.

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          Abstract

          A reduction of heart rate (HR) by surgical means or pharmacological agents affects the progression and/or regression of atherosclerotic lesions. Nevertheless, the effect of bradycardia per se on large artery structure and function has never been investigated in rat models of hypertension.

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          Association between high heart rate and high arterial rigidity in normotensive and hypertensive subjects.

          The dynamic elastic modulus of central arteries is very frequency-dependent Although resting heart rate is a potent independent risk factor for morbidity and mortality both from cardiovascular and from noncardiovascular disease, no link between tachycardia and arterial stiffness has ever been established. To relate arterial stiffness to heart rate in a population with relatively low cardiovascular risk. Pulse-wave velocity measurements and high-resolution echo-tracking techniques were used to determine the degree of arterial distension (of carotid and femoral arteries, and terminal aorta) and the velocity of the pulse wave (aorta and upper and lower limbs) at the same time as heart rate, in members of a large population of normotensive and hypertensive subjects in a multicenter study in Paris, Fleury-Merogis and Grenoble (France). A high heart rate was strongly associated with reduced distension and elevated pulse-wave velocity, even after adjustment for age and blood pressure. A high aortic pulse-wave velocity was also negatively associated with a low baroreflex sensitivity. The most significant associations between high heart rate and high arterial rigidity were found for the carotid artery, the thoracic aorta, and the lower limbs, but there was no significant result for the terminal aorta and the arm arteries. This study demonstrates that there is a statistically significant positive link between high heart rate and high arterial stiffness measured at the site of central and lower limb arteries. Since an elevated heart rate has been shown to be associated with cardiovascular risk, such findings may be relevant for future cardiovascular studies in epidemiology.
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            The static elastic properties of 45 human thoracic and 20 abdominal aortas in vitro and the parameters of a new model

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              Heart rate and the cardiovascular risk

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                Author and article information

                Journal
                J. Vasc. Res.
                Journal of vascular research
                S. Karger AG
                1018-1172
                1018-1172
                August 2 2003
                : 40
                : 4
                Affiliations
                [1 ] Department of Anesthesiology, Hôpital Beaujon, Clichy, France.
                Article
                72696
                10.1159/000072696
                12891001
                c5588fab-a578-4db1-8902-72df4259c22d
                History

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