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      Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.

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          Abstract

          Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet function, we hypothesized that ROCK2 in platelets will play important role in thrombosis and can be potentially a target for therapeutic intervention in thromboembolic stroke.

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          Author and article information

          Journal
          Cardiovasc. Res.
          Cardiovascular research
          Oxford University Press (OUP)
          1755-3245
          0008-6363
          Sep 01 2017
          : 113
          : 11
          Affiliations
          [1 ] Department of Medicine, Section of Cardiology, University of Chicago, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
          [2 ] Department of Medicine, Vascular Medicine Research Unit, Brigham and Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.
          [3 ] Department of Life Science, Ewha Womans University, 52 Ewhayeodae-gil, Daehyeon-dong, Seodaemun-gu, Seoul, Korea.
          [4 ] Department of Medicine, University of Massachusetts Medical School, 55 N. Lake Avenue, Worcester, MA 01655, USA.
          [5 ] Division of Hematology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
          [6 ] Department of Population Medicine, Medical University of Bialystok, Jana Kilinskiego 1, 15-089, Bialystok, Poland.
          Article
          3738279
          10.1093/cvr/cvx071
          5852540
          28430966

          Platelet, Atherosclerosis, Rho kinase, Stroke, Thrombosis

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