Laparoscopic resection of large gastric gastrointestinal stromal tumours.

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Abstract

Gastrointestinal stromal tumours (GISTs) are a rare class of neoplasms that are seen most commonly in the stomach. Due to their malignant potential, surgical resection is the recommended method for management of these tumours. Many reports have described the ability to excise small and medium sized GISTs laparoscopically, but laparoscopic resection of GISTs greater than 5 cm is still a matter of debate.

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Most cited references 22

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Diagnosis of gastrointestinal stromal tumors: A consensus approach.

D B Longley, Gordon J. Berman, Christopher Fletcher … (2002)

As a result of major recent advances in understanding the biology of gastrointestinal stromal tumors (GISTs), specifically recognition of the central role of activating KIT mutations and associated KIT protein expression in these lesions, and the development of novel and effective therapy for GISTs using the receptor tyrosine kinase inhibitor STI-571, these tumors have become the focus of considerable attention by pathologists, clinicians, and patients. Stromal/mesenchymal tumors of the gastrointestinal tract have long been a source of confusion and controversy with regard to classification, line(s) of differentiation, and prognostication. Characterization of the KIT pathway and its phenotypic implications has helped to resolve some but not all of these issues. Given the now critical role of accurate and reproducible pathologic diagnosis in ensuring appropriate treatment for patients with GIST, the National Institutes of Health convened a GIST workshop in April 2001 with the goal of developing a consensus approach to diagnosis and morphologic prognostication. Key elements of the consensus, as described herein, are the defining role of KIT immunopositivity in diagnosis and a proposed scheme for estimating metastatic risk in these lesions, based on tumor size and mitotic count, recognizing that it is probably unwise to use the definitive term "benign" for any GIST, at least at the present time. Copyright 2002, Elsevier Science (USA). All rights reserved.

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Spirituality in the cancer trajectory.

C.M. Puchalski (2012)

Spirituality is an essential element of person-centered care and a critical factor in the way patients with cancer cope with their illness from diagnosis through treatment, survival, recurrence and dying. Studies have indicated a significant relationship between spirituality and quality of life. Spirituality, in its broadest sense speaks to the meaning patients find in their lives especially during times of stress, illness and dying. Illness can trigger deep existential issues that could trigger profound suffering and distress. A model is presented that describes the role of each member of the healthcare team in addressing patients' spirituality. Spiritual distress, as a diagnosis, requires attention and treatment just as any other clinical symptom. Spiritual resources of strength need to be identifies and recognized as positive factors in patients' coping. Finally a treatment plan needs to include the spiritual as well as the physical and psychosocial issues of patients. Chaplains and other spiritual care professionals need to be recognized as the experts in spiritual care and should be integral members of the healthcare team. Integrating spirituality as an essential domain of care will result in better health outcomes, particularly quality of life for patients across the trajectory of cancer care.

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Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study.

R. Herings, W Goettsch, G Postma … (2005)

Gastrointestinal stromal tumours (GIST) are identified by their specific morphology added with immunohistochemical staining with anti-CD117, the phenotypic marker for GIST in the majority of cases. In this study the reported incidence of GIST and GIST-like tumours before and after the routine availability of the specific diagnostic marker CD117 antigen was investigated. All patients with GIST or GIST-like tumours were selected from PALGA, a nation-wide network and registry of histo- and cytopathology in the Netherlands, to calculate the incidence in 1995 and longitudinally over time between 1998 and 2003. Pathological reports were retrieved to assess the type of immunostaining used and to assess the risk category for malignant behaviour according to the recently published consensus criteria. The annual incidence of GIST as distilled from the national pathology registry increased from 2.1 per million inhabitants in 1995 to 12.7 per million inhabitants in 2003. The incidence of GIST-like tumours decreased from 17.6 per million inhabitants in 1995 to 12.7 per million inhabitants in 2003. The incidences were stable from 2000 onwards. Additional analysis in 2003 indicated that more than 90% of the GIST tested was CD117 positive, compared to only 4% of the GIST-like tumours. Almost 50% of the GIST was considered to be at high-risk for malignant behaviour, according to the consensus criteria. The increased incidence of GIST 1995-2003 is related to increased understanding of GIST pathobiology and the routine availability of the diagnostic immunohistochemical antibody directed against the CD117 antigen.

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Author and article information

Journal

Journal ID (iso-abbrev): Wideochir Inne Tech Maloinwazyjne

Title: Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

Publisher: Termedia Sp. z.o.o.

ISSN: 1895-4588

ISSN (Print): 1895-4588

Publication date (Electronic): 2016

Volume: 11

Issue: 1

Affiliations

[1 ] Connolly Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

[2 ] Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

[3 ] Saint John of God Hospital, Dublin, Ireland.

[4 ] Connolly Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland; Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.

Article

Publisher Item ID: 26396

DOI: 10.5114/wiitm.2015.56489

PMC ID: 4840182

PubMed ID: 28133498

SO-VID: 7d39cf96-bf6d-48fe-b1c4-99966618c83f

History

Keywords: sleeve gastrectomy,wedge resection,transgastric resection,gastrointestinal stromal tumour

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Keywords: sleeve gastrectomy, wedge resection, transgastric resection, gastrointestinal stromal tumour

Laparoscopic resection of large gastric gastrointestinal stromal tumours.

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Most cited references 22

Diagnosis of gastrointestinal stromal tumors: A consensus approach.

Spirituality in the cancer trajectory.

Incidence of gastrointestinal stromal tumours is underestimated: results of a nation-wide study.

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