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      International Journal of COPD (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on pathophysiological processes underlying Chronic Obstructive Pulmonary Disease (COPD) interventions, patient focused education, and self-management protocols. Sign up for email alerts here.

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      Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Hainan population: a case-control study.

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          Abstract

          Chronic obstructive pulmonary disease (COPD) is predicted to become the third most common cause of death and the fifth most common cause of disability in the world by 2020. Recently, variants in the hypoxia-inducible factor 1α (HIF1A), cholinergic receptor, neuronal nicotinic, alpha polypeptide-5, and iron-responsive element-binding protein 2 gene (IREB2) genes were found to be associated with COPD. This study aims to identify whether the variations in these genes are related to COPD in the Hainan population of the People's Republic of China.

          Most cited references16

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          High-throughput oncogene mutation profiling in human cancer.

          Systematic efforts are underway to decipher the genetic changes associated with tumor initiation and progression. However, widespread clinical application of this information is hampered by an inability to identify critical genetic events across the spectrum of human tumors with adequate sensitivity and scalability. Here, we have adapted high-throughput genotyping to query 238 known oncogene mutations across 1,000 human tumor samples. This approach established robust mutation distributions spanning 17 cancer types. Of 17 oncogenes analyzed, we found 14 to be mutated at least once, and 298 (30%) samples carried at least one mutation. Moreover, we identified previously unrecognized oncogene mutations in several tumor types and observed an unexpectedly high number of co-occurring mutations. These results offer a new dimension in tumor genetics, where mutations involving multiple cancer genes may be interrogated simultaneously and in 'real time' to guide cancer classification and rational therapeutic intervention.
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            Statistics notes. The odds ratio.

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              HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.

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                Author and article information

                Journal
                Int J Chron Obstruct Pulmon Dis
                International journal of chronic obstructive pulmonary disease
                Informa UK Limited
                1178-2005
                1176-9106
                2015
                : 10
                Affiliations
                [1 ] Department of Emergency, People's Hospital of Hainan Province, Haikou, Hainan, People's Republic of China.
                [2 ] Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
                [3 ] School of Life Sciences, Northwest University, Xi'an, People's Republic of China.
                [4 ] Department of Respiration, People's Hospital of Qionghai, Qionghai, Hainan, People's Republic of China.
                [5 ] School of Life Sciences, Northwest University, Xi'an, People's Republic of China ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, People's Republic of China.
                Article
                copd-10-007
                10.2147/COPD.S73042
                4279605
                25565795
                4ef1b18c-0256-4fda-8e40-3a076af8eeb2
                History

                HIF1A,IREB2,single nucleotide polymorphism (SNP)
                HIF1A, IREB2, single nucleotide polymorphism (SNP)

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