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      The interleukin 6 c.-174 CC genotype is a predictor for new cardiovascular events in patients with coronary heart disease within three years follow-up.

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          Abstract

          The main aim of this study was to evaluate putative associations between the interleukin (IL)-6 c.-174G>C polymorphism (rs 1800795) and the cardiovascular outcome (combined endpoint: myocardial infarction, stroke/TIA, cardiac death, death according to stroke) among patients with coronary heart disease (CHD) within three years follow-up. Overall 942 in-patients with CHD were included. The drop-out rate was 4.9%. The IL-6 polymorphism was determined with PCR-SSP. Kaplan-Meier plots with Log Rank test and Cox regression were used as statistically procedures. The IL-6 CC genotype was associated with a higher incidence of the combined endpoint (25.0% versus 13.5%, p<0.001) and an increased Hazard Ratio (HR 2.165, 95% CI 1.516-3.092, p<0.001) adjusted for established cofactors for CHD. This result suggests that the IL-6 -174 polymorphism is a putative independent risk indicator for new cardiovascular events among patients with CHD.

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          Author and article information

          Journal
          Cytokine
          Cytokine
          Elsevier BV
          1096-0023
          1043-4666
          July 2016
          : 83
          Affiliations
          [1 ] Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany. Electronic address: stefan.reichert@uk-halle.de.
          [2 ] Department of Cardiology, Paracelsus-Harz-Clinic Bad Suderode, Quedlinburg, Germany; Department of Internal Medicine III, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Germany.
          [3 ] Department of Operative Dentistry and Periodontology, Martin-Luther University Halle-Wittenberg, Germany.
          [4 ] Department of Cardiothoracic Surgery, Heart Centre of the University Clinics Halle (Saale), Martin-Luther-University Halle-Wittenberg, Germany.
          Article
          S1043-4666(16)30069-2
          10.1016/j.cyto.2016.04.011
          27131578
          f70dc8db-c9c7-4570-9971-f0a3e4398835
          Copyright © 2016 Elsevier Ltd. All rights reserved.
          History

          Coronary heart disease,Gene polymorphism,Interleukin-6,New cardiovascular events

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