Effect of Processing Delay and Storage Conditions on Urine Albumin-to-Creatinine Ratio.

Herrington, William; Illingworth, Nicola; Staplin, Natalie; Kumar, Aishwarya; Storey, Ben M; Hrusecka, Renata; Judge, Parminder; Mahmood, Maria; Parish, Sarah; Landray, Martin J; Haynes, Richard; Baigent, Colin; Hill, Michael L.; Clark, Sarah L.

doi:10.2215/CJN.13341215

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Effect of Processing Delay and Storage Conditions on Urine Albumin-to-Creatinine Ratio.

Author(s): William Herrington ¹ ^, ² , Nicola Illingworth ³ ^, ⁴ , Natalie Staplin ³ , Aishwarya Kumar ³ ^, ⁴ , Ben Storey ³ ^, ² ^, ⁴ , Renata Hrusecka ³ ^, ⁴ , Parminder Judge ³ ^, ² ^, ⁴ , Maria Mahmood ² , Sarah Parish ³ ^, ⁴ , Martin Landray ³ , Richard Haynes ³ ^, ² ^, ⁴ , Colin Baigent ³ ^, ⁴ , Michael Hill ³ ^, ⁴ , Sarah Clark ³ ^, ⁴

Publication date (Electronic): October 07 2016

Journal: Clinical journal of the American Society of Nephrology : CJASN

Publisher: American Society of Nephrology (ASN)

Keywords: Albumins, Boric Acids, Confidence Intervals, Freezing, Humans, Kidney Diseases, Randomized Controlled Trials as Topic, Specimen Handling, Temperature, Urinalysis, albuminuria, boric acid, creatinine, microalbuminuria, proteinuria, randomized controlled trials

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Abstract

Because there is substantial biologic intraindividual variation in albumin excretion, randomized trials of albuminuria-reducing therapies may need multiple urine samples to estimate daily urinary albumin excretion. Mailing spot urine samples could offer a convenient and cost-effective method to collect multiple samples, but urine albumin-to-creatinine ratio stability in samples stored at ambient temperatures for several days is unknown.

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Journal ID (iso-abbrev): Clin J Am Soc Nephrol

Title: Clinical journal of the American Society of Nephrology : CJASN

Publisher: American Society of Nephrology (ASN)

ISSN (Electronic): 1555-905X

ISSN (Print): 1555-9041

Publication date (Electronic): October 07 2016

Volume: 11

Issue: 10

Affiliations

[1 ] Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Oxford, United Kingdom; will.herrington@ndph.ox.ac.uk.

[2 ] Oxford Kidney Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom; and.

[3 ] Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, Oxford, United Kingdom.

[4 ] Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, Oxford, United Kingdom.

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Publisher Item ID: CJN.13341215

DOI: 10.2215/CJN.13341215

PMC ID: 5053802

PubMed ID: 27654930

SO-VID: 045068c7-7dcc-4b48-af0c-8341161e03ca

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Keywords: Kidney Diseases,Humans,Freezing,Confidence Intervals,Boric Acids,Albumins,randomized controlled trials,proteinuria,microalbuminuria,creatinine,boric acid,albuminuria,Urinalysis,Temperature,Specimen Handling,Randomized Controlled Trials as Topic

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Keywords: Kidney Diseases, Humans, Freezing, Confidence Intervals, Boric Acids, Albumins, randomized controlled trials, proteinuria, microalbuminuria, creatinine, boric acid, albuminuria, Urinalysis, Temperature, Specimen Handling, Randomized Controlled Trials as Topic

Effect of Processing Delay and Storage Conditions on Urine Albumin-to-Creatinine Ratio.

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