Lung volume reduction surgery and lung transplantation in chronic obstructive pulmonary disease

This international, peer-reviewed Open Access journal by Dove Medical Press focuses on pathophysiological processes underlying Chronic Obstructive Pulmonary Disease (COPD) interventions, patient focused education, and self-management protocols. Sign up for email alerts here.

39,063 Monthly downloads/views I 2.893 Impact Factor I 5.2 CiteScore I 1.16 Source Normalized Impact per Paper (SNIP) I 0.804 Scimago Journal & Country Rank (SJR)

Record: found
Abstract: found
Article: found

Is Open Access

Lung volume reduction surgery and lung transplantation in chronic obstructive pulmonary disease

review-article

Author(s): Jorge I Mora ¹ , Denis Hadjiliadis ²

Publication date (Electronic): December 2008

Journal: International Journal of Chronic Obstructive Pulmonary Disease

Publisher: Dove Medical Press

Keywords: COPD, emphysema, lung volume reduction, lung transplantation

Read this article at

ScienceOpen PMC

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Medical treatment of emphysema does not alter the natural progression of the disease. Surgical techniques are an attractive conceptual approach to treat hyperinflation in these patients. Lung volume reduction surgery and lung transplantation are appropriate therapeutic options for a selected population with emphysema. We will review the available evidence to support these approaches.

Most cited references 59

Record: found
Abstract: not found
Article: not found

International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation.

Allan R Glanville, Paul Corris, Scott Palmer … (2006)

0 comments Cited 157 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

The economic burden of COPD.

Sean D Sullivan, Scott Ramsey, Todd Lee (2000)

COPD is one of the leading causes of morbidity and mortality worldwide and imparts a substantial economic burden on individuals and society. Despite the intense interest in COPD among clinicians and researchers, there is a paucity of data on health-care utilization, costs, and social burden in this population. The total economic costs of COPD morbidity and mortality in the United States were estimated at $23.9 billion in 1993. Direct treatments for COPD-related illness accounted for $14.7 billion, and the remaining $9.2 billion were indirect morbidity and premature mortality estimated as lost future earnings. Similar data from another US study suggest that 10% of persons with COPD account for > 70% of all medical care costs. International studies of trends in COPD-related hospitalization indicate that although the average length of stay has decreased since 1972, admissions per 1,000 persons per year for COPD have increased in all age groups > 45 years of age. These trends reflect population aging, smoking patterns, institutional factors, and treatment practices.

0 comments Cited 139 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema.

Alfred P Fishman, Keith Naunheim, Robert Wise … (2003)

Lung-volume-reduction surgery has been proposed as a palliative treatment for severe emphysema. Effects on mortality, the magnitude and durability of benefits, and criteria for the selection of patients have not been established. A total of 1218 patients with severe emphysema underwent pulmonary rehabilitation and were randomly assigned to undergo lung-volume-reduction surgery or to receive continued medical treatment. Overall mortality was 0.11 death per person-year in both treatment groups (risk ratio for death in the surgery group, 1.01; P=0.90). After 24 months, exercise capacity had improved by more than 10 W in 15 percent of the patients in the surgery group, as compared with 3 percent of patients in the medical-therapy group (P<0.001). With the exclusion of a subgroup of 140 patients at high risk for death from surgery according to an interim analysis, overall mortality in the surgery group was 0.09 death per person-year, as compared with 0.10 death per person-year in the medical-therapy group (risk ratio, 0.89; P=0.31); exercise capacity after 24 months had improved by more than 10 W in 16 percent of patients in the surgery group, as compared with 3 percent of patients in the medical-therapy group (P<0.001). Among patients with predominantly upper-lobe emphysema and low exercise capacity, mortality was lower in the surgery group than in the medical-therapy group (risk ratio for death, 0.47; P=0.005). Among patients with non-upper-lobe emphysema and high exercise capacity, mortality was higher in the surgery group than in the medical-therapy group (risk ratio, 2.06; P=0.02). Overall, lung-volume-reduction surgery increases the chance of improved exercise capacity but does not confer a survival advantage over medical therapy. It does yield a survival advantage for patients with both predominantly upper-lobe emphysema and low base-line exercise capacity. Patients previously reported to be at high risk and those with non-upper-lobe emphysema and high base-line exercise capacity are poor candidates for lung-volume-reduction surgery, because of increased mortality and negligible functional gain. Copyright 2003 Massachusetts Medical Society

0 comments Cited 104 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Int J Chron Obstruct Pulmon Dis

Journal ID (publisher-id): International Journal of COPD

Title: International Journal of Chronic Obstructive Pulmonary Disease

Publisher: Dove Medical Press

ISSN (Print): 1176-9106

ISSN (Electronic): 1178-2005

Publication date (Print): December 2008

Publication date (Electronic): December 2008

Volume: 3

Issue: 4

Pages: 629-635

Affiliations

[1 ] Albert Einstein Medical Center, Philadelphia, PA, USA

[2 ] Hospital of the University of Pennsylvania, Philadelphia, PA, USA

Author notes

Correspondence: Denis Hadjiliadis, University of Pennsylvania. Division of Pulmonary, Allergy and Critical Care, Lung Transplant Program, Adult Cystic Fibrosis Program, Hospital of the University of Pennsylvania, 3400 Spruce Street, 835 W Gates Building, Philadelphia, PA, 19104, USA, Email denis.hadjiliadis@ 123456uphs.upenn.edu

Article

Publisher ID: copd-3-629

PMC ID: 2650594

PubMed ID: 19281079

SO-VID: 839f25a8-64bb-4c7c-986c-58beace5c0eb

History

Comments

Comment on this article

Cited by 4

See all cited by

Most referenced authors 857

See all reference authors

- Version 1
- Version 1

International Journal of COPD (submit here)

Lung volume reduction surgery and lung transplantation in chronic obstructive pulmonary disease

Read this article at

Abstract

Most cited references 59

International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation.

The economic burden of COPD.

A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema.

Author and article information

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 185

Cited by 4

Most referenced authors 857