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Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future. Copyright © 2012 Elsevier Inc. All rights reserved.

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PubMed ID:: 22682243

DOI:: 10.1016/j.cell.2012.05.012

ScienceOpen disciplines: Chemistry

Keywords: Animals,Disease,genetics,Humans,Wnt Proteins,metabolism,Wnt Signaling Pathway,beta Catenin

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Disease, genetics, Humans, Wnt Proteins, metabolism, Wnt Signaling Pathway, beta Catenin

Wnt/β-catenin signaling and disease.

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