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      X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging

      Parasitology
      Cambridge University Press (CUP)

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          Abstract

          X-ray micro-computed tomography ( μ CT) is a technique which can obtain three-dimensional images of a sample, including its internal structure, without the need for destructive sectioning. Here, we review the capability of the technique and examine its potential to provide novel insights into the lifestyles of parasites embedded within host tissue. The current capabilities and limitations of the technology in producing contrast in soft tissues are discussed, as well as the potential solutions for parasitologists looking to apply this technique. We present example images of the mouse whipworm Trichuris muris and discuss the application of μ CT to provide unique insights into parasite behaviour and pathology, which are inaccessible to other imaging modalities.

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          High-resolution X-ray computed tomography in geosciences: A review of the current technology and applications

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            Quantitative X-ray tomography

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              Drug resistance in veterinary helminths.

              At present, there is no effective alternative to chemical control of parasitic helminths where livestock are grazed intensively. Resistance to anthelmintics has become a major problem in veterinary medicine, and threatens both agricultural income and animal welfare. The molecular and biochemical basis of this resistance is not well understood. The lack of reliable biological and molecular tests means that we are not able to follow the emergence and spread of resistance alleles and clinical resistance as well as we need. This review summarizes some of the recent findings on resistance mechanisms, puts forward some recommendations for limiting its impact and suggests some priorities for research in this area.
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                Author and article information

                Journal
                10.1017/S0031182017002074

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