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      Stroke prevention worldwide – what could make it work?

      research-article
      , M.D., Ph.D, FAHA, FESO, , M.D., FAHA, FRACP, , M.D., MSc, Ph.D, FAAN, , M.D., FACC, , M.S, M.D., FAHA, FAAN, , M.D., Ph.D.
      Neuroepidemiology
      stroke, epidemiology, prevention, public health

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          Abstract

          The global burden of stroke is of continual major importance for global health. The present report adresses some of the core principles what could make stroke prevention work.

          The prevention of stroke shares many common features with other non-communicable diseases (NCDs); stroke prevention should therefore be part of the joint actions on NCD led by the WHO and member states. Stroke prevention is an integral part both of the 2011 UN declaration on actions on NCDs, and the UN Post-2015 Sustainable Developmental Goals. Stroke prevention requires an inter-sectorial approach, with important responsibilities both of governmental bodies, non-government organizations, the health sector proper, as well as communities, industry, and indivduals. Whereas official development assistance will need to be provided for the lowest income countries, for most countries financing will need to be raised by reallocation of resources within the country.

          Stroke is a prototype NCD in that there is overwhelming scientific evidence that with actions on risk factors the risk of stroke can be substantially reduced. Prevention of stroke will also have beneficial effects on cognitive decline and dementia. As most strokes do not lead to death, stroke statistics should not only focus on mortality, but also disability and quality of life. All preventive actions should start early in life and continue during the life cycle.

          Prevention of stroke is a complex medical and a political issue with many challenges. Upscaled efforts to prevent stroke are urgently needed in all regions, and the opportunity to act is now.

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          Most cited references4

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          The global burden of hemorrhagic stroke: a summary of findings from the GBD 2010 study.

          This report summarizes the findings of the GBD 2010 (Global Burden of Diseases, Injuries, and Risk Factors) study for hemorrhagic stroke (HS). Multiple databases were searched for relevant studies published between 1990 and 2010. The GBD 2010 study provided standardized estimates of the incidence, mortality, mortality-to-incidence ratios (MIR), and disability-adjusted life years (DALY) lost for HS (including intracerebral hemorrhage and subarachnoid hemorrhage) by age, sex, and income level (high-income countries [HIC]; low- and middle-income countries [LMIC]) for 21 GBD 2010 regions in 1990, 2005, and 2010. In 2010, there were 5.3 million cases of HS and over 3.0 million deaths due to HS. There was a 47% increase worldwide in the absolute number of HS cases. The largest proportion of HS incident cases (80%) and deaths (63%) occurred in LMIC countries. There were 62.8 million DALY lost (86% in LMIC) due to HS. The overall age-standardized incidence rate of HS per 100,000 person-years in 2010 was 48.41 (95% confidence interval [CI]: 45.44 to 52.13) in HIC and 99.43 (95% CI: 85.37 to 116.28) in LMIC, and 81.52 (95% CI: 72.27 to 92.82) globally. The age-standardized incidence of HS increased by 18.5% worldwide between 1990 and 2010. In HIC, there was a reduction in incidence of HS by 8% (95% CI: 1% to 15%), mortality by 38% (95% CI: 32% to 43%), DALY by 39% (95% CI: 32% to 44%), and MIR by 27% (95% CI: 19% to 35%) in the last 2 decades. In LMIC countries, there was a significant increase in the incidence of HS by 22% (95% CI: 5% to 30%), whereas there was a significant reduction in mortality rates of 23% (95% CI: -3% to 36%), DALY lost of 25% (95% CI: 7% to 38%), and MIR by 36% (95% CI: 16% to 49%). There were significant regional differences in incidence rates of HS, with the highest rates in LMIC regions such as sub-Saharan Africa and East Asia, and lowest rates in High Income North America and Western Europe. The worldwide burden of HS has increased over the last 2 decades in terms of absolute numbers of HS incident events. The majority of the burden of HS is borne by LMIC. Rates for HS incidence, mortality, and DALY lost, as well as MIR decreased in the past 2 decades in HIC, but increased significantly in LMIC countries, particularly in those patients ≤75 years. HS affected people at a younger age in LMIC than in HIC. The lowest incidence and mortality rates in 2010 were in High Income North America, Australasia, and Western Europe, whereas the highest rates were in Central Asia, Southeast Asia, and sub-Saharan Africa. These results suggest that reducing the burden of HS is a priority particularly in LMIC. The GBD 2010 findings may be a useful resource for planning strategies to reduce the global burden of HS.
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            The World Heart Federation's vision for worldwide cardiovascular disease prevention.

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              Primary Preventive Potential for Stroke by Avoidance of Major Lifestyle Risk Factors: The European Prospective Investigation Into Cancer and Nutrition-Heidelberg Cohort

              Because primary prevention of stroke is a priority, our aim was to assess the primary preventive potential of major lifestyle risk factors for stroke in middle-aged women and men.
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                Author and article information

                Contributors
                Journal
                8218700
                6054
                Neuroepidemiology
                Neuroepidemiology
                Neuroepidemiology
                0251-5350
                1423-0208
                26 January 2016
                28 October 2015
                2015
                28 October 2016
                : 45
                : 3
                : 215-220
                Affiliations
                Professor in Neurology, Department of Clinical Sciences, Neurology, Lund University, Lund, Sweden
                Professor of Translational Neuroscience, Melbourne Brain Centre, Royal Melbourne Hospital and University of Melbourne
                Professor of Epidemiology and Neurology, National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, Auckland University of Technology, Private Bag 92006, Auckland, New Zealand
                Director, Center for Translation Researchand Implementation Science (CTRIS), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
                Olemberg Family Chair in Neurological Disorders and Chairman of Neurology, Chief of Neurology, Jackson Memorial Hospital, Executive Director, Evelyn McKnight Brain Institute, Miller Professor of Neurology, Epidemiology, and Human Genetics, University of Miami
                Coordinator, Management of Noncommunicable Diseases, World Health Organization, CH-1211 Geneva, Switzerland, Geneva
                Author notes
                Corresponding author: Bo Norrving, Bo.norrving@ 123456med.lu.se
                Article
                PMC4734746 PMC4734746 4734746 nihpa726303
                10.1159/000441104
                4734746
                26505459
                a7265bbc-12ea-44fb-bb5c-072442c9bc75
                History
                Categories
                Article

                stroke,epidemiology,prevention,public health
                stroke, epidemiology, prevention, public health

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