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      An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells.

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          Abstract

          Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells). Immobilized Kupffer cells with highly ramified extended processes into multiple sinusoids could effectively capture blood-borne, disseminating Borrelia burgdorferi, creating a highly efficient surveillance and filtering system. After ingesting B. burgdorferi, Kupffer cells induced chemokine receptor CXCR3-dependent clustering of iNKT cells. Kupffer cells and iNKT cells formed stable contacts via the antigen-presenting molecule CD1d, which led to iNKT cell activation. An absence of iNKT cells caused B. burgdorferi to leave the blood and enter the joints more effectively. B. burgdorferi that escaped Kupffer cells entered the liver parenchyma and survived despite Ito cell responses. Kupffer cell-iNKT cell interactions induced a key intravascular immune response that diminished the dissemination of B. burgdorferi.

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          Author and article information

          Journal
          Nat Immunol
          Nature immunology
          Springer Science and Business Media LLC
          1529-2916
          1529-2908
          Apr 2010
          : 11
          : 4
          Affiliations
          [1 ] Department of Physiology & Pharmacology, University of Calgary, Alberta, Canada.
          Article
          ni.1855 CAMS2458
          10.1038/ni.1855
          5114121
          20228796
          8e1989d6-b4ba-4ef6-85e0-c58f13d250e3
          History

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