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      Adapting to obesity with adipose tissue inflammation.

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          Abstract

          Adipose tissue not only has an important role in the storage of excess nutrients but also senses nutrient status and regulates energy mobilization. An overall positive energy balance is associated with overnutrition and leads to excessive accumulation of fat in adipocytes. These cells respond by initiating an inflammatory response that, although maladaptive in the long run, might initially be a physiological response to the stresses obesity places on adipose tissue. In this Review, we characterize adipose tissue inflammation and review the current knowledge of what triggers obesity-associated inflammation in adipose tissue. We examine the connection between adipose tissue inflammation and the development of insulin resistance and catecholamine resistance and discuss the ensuing state of metabolic inflexibility. Finally, we review the current and potential new anti-inflammatory treatments for obesity-associated metabolic disease.

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          Author and article information

          Journal
          Nat Rev Endocrinol
          Nature reviews. Endocrinology
          Springer Science and Business Media LLC
          1759-5037
          1759-5029
          Nov 2017
          : 13
          : 11
          Affiliations
          [1 ] Department of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.
          Article
          nrendo.2017.90
          10.1038/nrendo.2017.90
          28799554
          fe233079-7ba2-4e3b-810a-a4b0fed73229
          History

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