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      Alpha-1-antitrypsin deficiency associated with hepatic cirrhosis and IgA nephritis.

      1 , , ,
      Nephron
      S. Karger AG

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          Abstract

          The association between alpha1-antitrypsin (A1AT) deficiency and glomerulonephritis has only sporadically been reported, and mostly based upon autopsy findings, as opposed to the more frequent linkage between A1AT deficiency and lung emphysema with or without hepatic cirrhosis. The present case report describes a 30-year-old man with A1AT deficiency, without evidence of lung disease, who developed hepatic cirrhosis in early childhood and IgA glomerulonephritis and hypertension in adult life. The IgA nephritis followed an unusual course, with a sudden deterioration of the renal function, possibly induced by uncontrolled hypertension or the possible occurrence of vasculitis. After 6 months of hemodialysis, the patient successfully underwent living-related-donor kidney transplantation.

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          Author and article information

          Journal
          Nephron
          Nephron
          S. Karger AG
          1660-8151
          1660-8151
          1997
          : 77
          : 2
          Affiliations
          [1 ] Department of Internal Medicine, Ullevål Hospital, Oslo, Norway.
          Article
          10.1159/000190278
          9346392
          4ba2229b-0ad3-4f5b-b20a-867541360b4c
          History

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