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      Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.

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          Abstract

          The apicomplexan parasite Plasmodium falciparum causes the most severe form of malaria in humans. After invasion into erythrocytes, asexual parasite stages drastically alter their host cell and export remodeling and virulence proteins. Previously, we have reported identification and functional analysis of a short motif necessary for export of proteins out of the parasite and into the red blood cell.

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          Profile hidden Markov models.

          S. Eddy (1998)
          The recent literature on profile hidden Markov model (profile HMM) methods and software is reviewed. Profile HMMs turn a multiple sequence alignment into a position-specific scoring system suitable for searching databases for remotely homologous sequences. Profile HMM analyses complement standard pairwise comparison methods for large-scale sequence analysis. Several software implementations and two large libraries of profile HMMs of common protein domains are available. HMM methods performed comparably to threading methods in the CASP2 structure prediction exercise.
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            Measuring the accuracy of diagnostic systems.

            J Swets (1988)
            Diagnostic systems of several kinds are used to distinguish between two classes of events, essentially "signals" and "noise". For them, analysis in terms of the "relative operating characteristic" of signal detection theory provides a precise and valid measure of diagnostic accuracy. It is the only measure available that is uninfluenced by decision biases and prior probabilities, and it places the performances of diverse systems on a common, easily interpreted scale. Representative values of this measure are reported here for systems in medical imaging, materials testing, weather forecasting, information retrieval, polygraph lie detection, and aptitude testing. Though the measure itself is sound, the values obtained from tests of diagnostic systems often require qualification because the test data on which they are based are of unsure quality. A common set of problems in testing is faced in all fields. How well these problems are handled, or can be handled in a given field, determines the degree of confidence that can be placed in a measured value of accuracy. Some fields fare much better than others.
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              Human malaria parasites in continuous culture.

              W Trager, Jens-Erik B Jensen, Louise Jensen (1976)
              Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen (1 or 5 percent). The original parasite material, derived from an infected Aotus trivirgatus monkey, was diluted more than 100 million times by the addition of human erythrocytes at 3- or 4-day intervals. The parasites continued to reproduce in their normal asexual cycle of approximately 48 hours but were no longer highly synchronous. The have remained infective to Aotus.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Genome Biol
                Title: Genome biology
                Publisher: Springer Science and Business Media LLC
                ISSN (Electronic): 1474-760X
                ISSN (Print): 1474-7596
                Publication date (Electronic): 2006
                Volume: 7
                Issue: 2
                Affiliations
                [1 ] The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia. sarjeant@wehi.edu.au
                Article
                Publisher Item ID: gb-2006-7-2-r12
                DOI: 10.1186/gb-2006-7-2-r12
                PMC ID: 1431722
                PubMed ID: 16507167
                SO-VID: cbca9dc4-7524-49a1-b695-45c67fc36f24
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