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      Metazoan MicroRNAs

      research-article
      1 , 2
      Cell

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          Abstract

          MicroRNAs (miRNAs) are ~22-nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

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          Author and article information

          Journal
          0413066
          2830
          Cell
          Cell
          Cell
          0092-8674
          1097-4172
          14 March 2018
          22 March 2018
          22 March 2019
          : 173
          : 1
          : 20-51
          Affiliations
          [1 ]Howard Hughes Medical Institute and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142
          [2 ]Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139
          Author notes
          [* ]Correspondence: dbartel@ 123456wi.mit.edu
          Article
          PMC6091663 PMC6091663 6091663 nihpa948672
          10.1016/j.cell.2018.03.006
          6091663
          29570994
          7ed2fb32-20c7-45ef-b7ec-1de10358db73
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