Metazoan MicroRNAs

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Abstract

MicroRNAs (miRNAs) are ~22-nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution. It then reviews how metazoan miRNAs are regulated, how they recognize and cause repression of their targets, and the biological functions of this repression, with a compilation of knockout phenotypes that shows that important biological functions have been identified for most of the broadly conserved miRNAs of mammals.

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Journal

Journal ID (nlm-journal-id): 0413066

Journal ID (pubmed-jr-id): 2830

Journal ID (nlm-ta): Cell

Journal ID (iso-abbrev): Cell

Title: Cell

ISSN (Print): 0092-8674

ISSN (Electronic): 1097-4172

Publication date Nihms-submitted: 14 March 2018

Publication date (Print): 22 March 2018

Publication date PMC-release: 22 March 2019

Volume: 173

Issue: 1

Pages: 20-51

Affiliations

[1 ]Howard Hughes Medical Institute and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142

[2 ]Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139

Author notes

[* ]Correspondence: dbartel@ 123456wi.mit.edu

Article

Accession ID: PMC6091663 Pmcid ID: PMC6091663 Pmc-uid ID: 6091663 Manuscript ID: nihpa948672

DOI: 10.1016/j.cell.2018.03.006

PMC ID: 6091663

PubMed ID: 29570994

SO-VID: 7ed2fb32-20c7-45ef-b7ec-1de10358db73

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