Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Little is known about the origin of pancreatic intraductal papillary mucinous neoplasms (IPMN). Pancreatic duct glands (PDGs) are gland-like outpouches budding off the main pancreatic ducts that function as a progenitor niche for the ductal epithelium; they express gastric mucins and have characteristics of side-branch IPMNs. We investigated whether PDGs are a precursor compartment for IPMNs and the role of Trefoil factor family 2 (TFF2)-a protein expressed by PDGs and the gastric mucosa that are involved in epithelial repair and tumor suppression.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): December 2016

Volume: 151

Issue: 6

Affiliations

[1 ] Department of Surgery, Andrew L. Warshaw Institute for Pancreatic Cancer Research, Massachusetts General Hospital, Boston, Massachusetts.

[2 ] Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts.

[3 ] Division of Surgical Oncology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.

[4 ] Division of Digestive and Liver Diseases and Irving Cancer Research Center, Columbia University Medical Center, New York, New York.

[5 ] Department of Surgery, Andrew L. Warshaw Institute for Pancreatic Cancer Research, Massachusetts General Hospital, Boston, Massachusetts; Division of Surgical Oncology and the Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska. Electronic address: sarah.thayer@unmc.edu.

Article

Publisher Item ID: S0016-5085(16)34898-3 Mid ID: NIHMS810151

DOI: 10.1053/j.gastro.2016.07.045

PMC ID: 5396548

PubMed ID: 27523981

SO-VID: 2ef6e96b-bf68-4ceb-b220-a2be31eec33e

History

Keywords: Carcinogenesis,Gene Regulation,PanIN,Pancreatic Tumorigenesis

Data availability:

Keywords: Carcinogenesis, Gene Regulation, PanIN, Pancreatic Tumorigenesis

Comments

Comment on this article

scite_

Cited by 17

See all cited by

- Version 1