Rising pregabalin use and misuse in Australia: trends in utilization and intentional poisonings.

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Abstract

Pregabalin is a gamma-aminobutyric acid (GABA) analogue, used to treat neuropathic pain and epilepsy. Pregabalin was registered in Australia in 2005, and subsidized publically in 2013. We aimed to describe Australian patterns of pregabalin use and intentional poisoning, and identify people potentially at high risk of misuse.

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Most cited references 33

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The Australian Pharmaceutical Benefits Scheme data collection: a practical guide for researchers

Leigh Mellish, Emily Karanges, Melisa J. Litchfield … (2015)

Background The Pharmaceutical Benefits Scheme (PBS) is Australia’s national drug subsidy program. This paper provides a practical guide to researchers using PBS data to examine prescribed medicine use. Findings Excerpts of the PBS data collection are available in a variety of formats. We describe the core components of four publicly available extracts (the Australian Statistics on Medicines, PBS statistics online, section 85 extract, under co-payment extract). We also detail common analytical challenges and key issues regarding the interpretation of utilisation using the PBS collection and its various extracts. Conclusions Research using routinely collected data is increasing internationally. PBS data are a valuable resource for Australian pharmacoepidemiological and pharmaceutical policy research. A detailed knowledge of the PBS, the nuances of data capture, and the extracts available for research purposes are necessary to ensure robust methodology, interpretation, and translation of study findings into policy and practice.

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Abuse and Misuse of Pregabalin and Gabapentin

Kirk E Evoy, Stephen Saklad, Megan D. Morrison (2017)

Gabapentinoid (pregabalin and gabapentin) abuse is increasingly being reported.

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Gabapentin and Pregabalin for Pain - Is Increased Prescribing a Cause for Concern?

Christopher W Goodman, Allan S Brett (2017)

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Author and article information

Journal

Journal ID (iso-abbrev): Addiction

Title: Addiction (Abingdon, England)

Publisher: Wiley

ISSN (Electronic): 1360-0443

ISSN (Print): 0965-2140

Publication date (Electronic): June 2019

Volume: 114

Issue: 6

Affiliations

[1 ] New South Wales Poisons Information Centre, The Children's Hospital at Westmead, Westmead, NSW, Australia.

[2 ] Clinical Pharmacology and Toxicology Research Group, Discipline of Pharmacology, School of Medical Sciences, Sydney Medical School, University of Sydney, NSW, Australia.

[3 ] Centre for Big Data Research in Health, University of New South Wales, Sydney, Australia.

[4 ] Clinical Toxicology Research Group, Faculty of Health and Medicine, University of Newcastle, Australia.