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      A new method for induced fit docking (GENIUS) and its application to virtual screening of novel HCV NS3-4A protease inhibitors.

      Bioorganic & Medicinal Chemistry

      chemistry, antagonists & inhibitors, Viral Nonstructural Proteins, Structure-Activity Relationship, pharmacology, Serine Proteinase Inhibitors, Protein Conformation, Humans, drug therapy, Hepatitis C, Drug Evaluation, Preclinical, Drug Design, Antiviral Agents

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          Abstract

          Hepatitis C virus (HCV) is an etiologic agent of chronic liver disease, and approximately 170 million people worldwide are infected with the virus. HCV NS3-4A serine protease is essential for the replication of this virus, and thus has been investigated as an attractive target for anti-HCV drugs. In this study, we developed our new induced-fit docking program (genius), and applied it to the discovery of a new class of NS3-4A protease inhibitors (IC(50)=1-10 μM including high selectivity index). The new inhibitors thus identified were modified, based on the docking models, and revealed preliminary structure-activity relationships. Moreover, the genius in silico screening performance was validated by using an enrichment factor. We believe our designed scaffold could contribute to the improvement of HCV chemotherapy. Copyright © 2011 Elsevier Ltd. All rights reserved.

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          Journal
          10.1016/j.bmc.2011.09.023
          21992802

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