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      Pulmonary effects of furosemide in preterm infants with lung disease.

      The Journal of Pediatrics
      Furosemide, therapeutic use, Humans, Infant, Newborn, Lung Compliance, drug effects, Random Allocation, Respiration, Respiratory Distress Syndrome, Newborn, drug therapy

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          Abstract

          Twenty preterm infants recovering from respiratory distress syndrome at 1 week of age were randomized in this study either to a control or a treatment group. Those treated received a single daily dose of furosemide (1 mg/kg) intravenously. Pulmonary compliance was observed to improve significantly at two hours in the treated group, as compared with that in the controls. The calculated alveolar-arterial oxygen gradient was noted to decrease two hours after furosemide and to remain decreased over the four-day period in the treated group. This improvement in lung function was not secondary to diuresis in the infants treated with furosemide. We conclude that furosemide may have a direct pulmonary effect and improve lung function acutely as well as with chronic administration.

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