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      Growth hormone deficiency (GHD) from birth to 2 years of age: diagnostic specifics of GHD during the early phase of life.

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      Hormone research
      S. Karger AG

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          Abstract

          The first 2 years of life represent a transition period when growth changes from predominantly growth hormone (GH) independent to GH dependent. In the fetus, growth is influenced by genetic and environmental factors in addition to nutrition and growth factors including insulin. In infancy, nutrition remains an important determinant of growth. GH levels are high in mid-gestation and at birth, then fall sharply for the first few weeks and more slowly over the next few months reaching pre-pubertal levels by around the age of 6 months. GH deficiency (GHD) may present at birth with hypoglycaemia, micropenis or prolonged conjugated hyperbilirubinaemia. Although length at birth is usually within the normal centile ranges, post-natal growth failure can begin early and be profound.

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          Most cited references12

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          Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

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            Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Society

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              • Abstract: not found
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              Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth

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                Author and article information

                Journal
                Horm. Res.
                Hormone research
                S. Karger AG
                0301-0163
                0301-0163
                2003
                : 60
                : Suppl 1
                Affiliations
                [1 ] Rosie Hospital, Addenbrooke's NHS Trust, Cambridge, UK. amanda.ogilvy-stuart@addenbrookes.nhs.uk
                Article
                71219
                10.1159/000071219
                12955011
                220ba9a2-0a70-49e8-895c-6ab1c326d25e
                History

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