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Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters.
D Rothenbacher
1 ,
H G Fischer ,
A Hoffmeister ,
M M Hoffmann ,
W März ,
G Bode ,
J Rosenthal ,
W Koenig ,
H Brenner
May 2002
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Abstract
It has been suggested that homocysteine (tHcy) levels and methylenetetrahydrofolate reductase (MTHFR) genotype are primary risk factors for coronary heart disease (CHD). We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding.