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      Mechanisms of improved physical performance of chronic hemodialysis patients after erythropoietin treatment.

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          Abstract

          Correction of the anemia that is common among chronic hemodialysis patients by treatment with human recombinant erythropoietin (rHuEPO), even if incomplete, improves physical performance of patients. Oxygen uptake and physical work capacity at maximal work loads and at the anaerobic threshold increase by approximately 20%. Analysis of underlying mechanisms by pulmonary function tests and ergospirometry demonstrate that improved oxygen transport in the blood and its concomitant changes of the anaerobic threshold and heart rate appear to be main causes of improvement. Parameters of respiratory mechanics and gas exchange remain essentially unaltered.

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          Author and article information

          Journal
          Am. J. Nephrol.
          American journal of nephrology
          S. Karger AG
          0250-8095
          0250-8095
          1990
          : 10 Suppl 2
          Affiliations
          [1 ] Department of Internal Medicine III, Klinikum der Universität Heidelberg, FRG.
          Article
          10.1159/000168211
          2124412
          0b640233-a7b0-4e23-aee5-0e51ec24370d
          History

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