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      Age-related changes in central nervous system beta-endorphin and ACTH.

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      Neuroendocrinology

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          Abstract

          Aging is associated with alterations in mood, thermoregulation, pain threshold, and stress response. Because these functions may be modulated by endogenous opiates, we measured immunoreactive ACTH with beta-endorphin in discrete brain areas and pituitary glands from rats aged 6 weeks (young), 6 months (mature), and 20-24 months (senscent). Beta-Endorphin and ACTH declined significantly with aging in the hypothalamus and corpus striatum. Beta-Endorphin and ACTH increased in the frontal lobe during early life; however, no change was noted after maturity. A discordant response with age was noted in the pituitary in that (ACTH did not change, while beta-endorphin increased early in life without change after maturity. Cerebellar tissue exhibited no immunoreactive ACTH or beta-endorphin. Age-related changes in brain and pituitary beta-endorphin and ACTH must be considered in the evaluation of the physiological aging process and when comparing studies of these neuropeptides.

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          Author and article information

          Journal
          Neuroendocrinology
          Neuroendocrinology
          0028-3835
          0028-3835
          Oct 1980
          : 31
          : 4
          Article
          6252495
          7d2609c8-4731-4f5b-a3d7-3b60a6c85471
          History

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