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      TRAIL agonists on clinical trials for cancer therapy: the promises and the challenges.

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          Abstract

          Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is normally expressed in the human immune system and plays a critical role in antitumor immunity. TRAIL interacts with the death receptors, DR4 and DR5, and activates intracellular apoptotic pathway in cancer cells. This discovery has resulted in a rapid development of cancer therapeutic agents that can activate this apoptotic pathway. These therapeutic agents include recombinant human TRAIL (rhTRAIL) and its agonistic monoclonal antibody (MAb) against DR4 and DR5. Phase I trials have established the safety and tolerability of these TRAIL agonists in patients. Phase II trials are currently evaluating the therapeutic efficacy of TRAIL agonists as single agents or in combination with established cancer therapeutics. This review outlines the advances and the challenges in the development of these TRAIL agonists as effective clinical cancer therapeutics.

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          Author and article information

          Journal
          Rev Recent Clin Trials
          Reviews on recent clinical trials
          Bentham Science Publishers Ltd.
          1574-8871
          1574-8871
          Jan 2009
          : 4
          : 1
          Affiliations
          [1 ] Department of Pathology & Laboratory Medicine, 1365-C Clifton Road, Atlanta, GA, USA.
          Article
          10.2174/157488709787047530
          19149761
          51bc1a8d-c640-464a-a943-cc79f70f90ba
          History

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