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      Immunology of asthma and chronic obstructive pulmonary disease.

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      Nature reviews. Immunology
      Springer Science and Business Media LLC

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          Abstract

          Asthma and chronic obstructive pulmonary disease (COPD) are both obstructive airway diseases that involve chronic inflammation of the respiratory tract, but the type of inflammation is markedly different between these diseases, with different patterns of inflammatory cells and mediators being involved. As described in this Review, these inflammatory profiles are largely determined by the involvement of different immune cells, which orchestrate the recruitment and activation of inflammatory cells that drive the distinct patterns of structural changes in these diseases. However, it is now becoming clear that the distinction between these diseases becomes blurred in patients with severe asthma, in asthmatic subjects who smoke and during acute exacerbations. This has important implications for the development of new therapies.

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          Author and article information

          Journal
          Nat Rev Immunol
          Nature reviews. Immunology
          Springer Science and Business Media LLC
          1474-1741
          1474-1733
          Mar 2008
          : 8
          : 3
          Affiliations
          [1 ] Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK. p.j.barnes@imperial.ac.uk
          Article
          nri2254
          10.1038/nri2254
          18274560
          1024995f-13da-4f96-aaee-2c7fa15de202

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