Six new monacolin analogs from red yeast rice

Abstract

Six novel monacolin analogs, monacolins V 1 -V 6 ( 1–6 ), together with seven known ones ( 7–13 ), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR ( 1 H- 1 HCOSY, HSQC, HMBC, and NOESY/ROESY) and CD spectroscopic analyses as well as chemical derivation. Monacolins V 2 ( 2 ) and V 3 ( 3 ) represent the first examples of monacolins with 3-hydroxybutyrate substitute. The anti-inflammatory inhibitory activities against the lipopolysaccharide (LPS) induced NO production in BV-2 cells as well as antioxidant activities against rat liver microsomal lipid peroxidation were evaluated.