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      89 Zr-ImmunoPET companion diagnostics and their impact in clinical drug development.

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          Abstract

          Therapeutic monoclonal antibodies have been used in cancer treatment for 30 years, with around 24 mAb and mAb:drug conjugates approved by the FDA to date. Despite their specificity, efficacy has remained limited, which, in part, derails nascent initiatives towards precision medicine. An image-guided approach to reinforce treatment decisions using immune positron emission tomography (immunoPET) companion diagnostic is warranted. This review provides a general overview of current translational research using Zr-89 immunoPET and opportunities for utilizing and harnessing this tool to its full potential. Patient case studies are cited to illustrate immunoPET probes as tools for profiling molecular signatures. Discussions on its utility in reinforcing clinical decisions as it relates to histopathological tumor assessment and standard diagnostic methods, and its potential as predictive biomarkers, are presented. We finally conclude with an overview of practical considerations to its utility in the clinic.

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          Author and article information

          Journal
          J Labelled Comp Radiopharm
          Journal of labelled compounds & radiopharmaceuticals
          Wiley
          1099-1344
          0362-4803
          Jul 2018
          : 61
          : 9
          Affiliations
          [1 ] Cancer Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.
          [2 ] Department of Oncology, Karmanos Cancer Institute, Detroit, Michigan, USA.
          Article
          NIHMS935614
          10.1002/jlcr.3605
          6050145
          29341222
          ad433168-1864-4e22-bc5a-e875cbc3c6e1
          History

          ImmunoPET,clinical trials,companion diagnostics,imaging,antibody

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