76
views
0
recommends
+1 Recommend
0 collections
    3
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery.

      Advanced Materials (Deerfield Beach, Fla.)
      Animals, Biocompatible Materials, adverse effects, chemical synthesis, chemistry, Drug Carriers, Humans, Nanomedicine, methods, Nanoparticles, Porosity, Silicon Dioxide

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more and more attention for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs as drug delivery systems (DDSs) show significant advantages over traditional drug nanocarriers. In this review, we overview the recent progress in the synthesis of MSNs for drug delivery applications. First, we provide an overview of synthesis strategies for fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure. The review also highlights the significant achievements in drug delivery using mesoporous silica nanoparticles and their multifunctional counterparts as drug carriers. In particular, the biological barriers for nano-based targeted cancer therapy and MSN-based targeting strategies are discussed. We conclude with our personal perspectives on the directions in which future work in this field might be focused. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

          Related collections

          Author and article information

          Journal
          22378538
          10.1002/adma.201104763

          Chemistry
          Animals,Biocompatible Materials,adverse effects,chemical synthesis,chemistry,Drug Carriers,Humans,Nanomedicine,methods,Nanoparticles,Porosity,Silicon Dioxide

          Comments

          Comment on this article