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      Evidence for Endothelium-Dependent Vasodilation of Resistance Vessels by Acetylcholine

      , , ,
      Journal of Vascular Research
      S. Karger AG

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          Abstract

          In the perfused mesenteric arterial vasculature of the rabbit, vasodilation by acetylcholine (ACh) was almost completely blocked after a 15-min perfusion of the vasculature with 0.2% collagenase, an enzyme capable of removing endothelial cells. In the perfused mesenteric arterial vasculature of the rat, vasodilation by ACh was markedly, though not completely, inhibited by hemoglobin (10 µ M ), an agent which can inactivate endothelium-derived relaxing factor (EDRF). These results suggest that a major component of vasodilation of mesenteric resistance vessels in rabbit and rat by ACh is mediated by EDRF.

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          Author and article information

          Journal
          Journal of Vascular Research
          Blood Vessels
          S. Karger AG
          1423-0135
          1018-1172
          1987
          1987
          : 24
          : 3
          : 145-149
          Article
          10.1159/000158689
          67d137e0-7855-4221-958e-e0fb842fedaf
          © 1987
          History

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