A woman, aged 57, reported a considerable loss of vision in her right eye within approx. 60 s after lying down. She regained vision in the upright position within approx. 90 s. The Ganzfeld ERG, recorded in the upright position, showed a moderately reduced amplitude, but was entirely absent when recorded in the supine position, closely correlated to the subjective fading of the vision. Although all other clinical tests revealed no further hint to the cause of this remarkable amaurosis fugax, a temporary hypoxy of the retina due to circulatory deficiencies is suspected.