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      Photoanthropometric Study of Dysmorphic Features of the Face in Children with Autism and Asperger Syndrome

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          Abstract

          Objective

          Childhood autism is a neurodevelopmental disorder characterized by impairments in social interactions, verbal and non-verbal communication and by a pattern of stereotypical behaviors and interests. The aim of this study was to estimate the dysmorphic facial features of children with autism and children with Asperger syndrome.

          Methods

          The examination was conducted on 60 children (30 with childhood autism and 30 with Asperger syndrome). The photo anthropometric method used in this study followed the protocol established by Stengel-Rutkowski et al.

          Results

          The performed statistical analysis showed that in patients with childhood autism, the anteriorly rotated ears and the long back of the nose appeared more often. In the group of children with autism, there was a connection between the amount of dysmorphies and the presence of some somatic diseases in the first-degree relatives. There was also a connection between the motor coordination and the age the child began to walk.

          Discussion

          In patients with childhood autism, there were certain dysmorphies (like the anterior rotated ears and the long back of the nose) which appeared more often. Although the connection was not statistically significant, it seemed to concur with data from the literature.

          Conclusion

          Formulation of the other conclusions would require broader studies e.g. dealing with a familial analysis of dysmorphic features.

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          Most cited references40

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          Diagnostic and statistical manual of mental disorders.

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            2nd to 4th digit ratios, fetal testosterone and estradiol.

            The ratio of 2nd to 4th digit length (2D:4D) is sexually dimorphic (mean 2D:4D is lower in males than females) and is thought to be fixed early in development. 2D:4D has been reported to be related to fetal growth, hand preference, autism, Asperger's syndrome, sperm counts, family size, age at myocardial infarction in men and breast cancer in women. There is indirect evidence that 2D:4D is established in utero and is negatively related to prenatal testosterone and positively with prenatal estradiol. However, there are no studies which show direct relationships between fetal testosterone (FT), fetal estradiol (FE) and 2D:4D. To investigate the relationships between 2D:4D ratios and FT and FE from amniotic fluid. Cohort study. 33 children. Radioimmunoassays of FT and FE obtained from routine amniocentesis; 2D:4D ratios calculated from 2nd and 4th digit length of the right and left hands at age 2 years. A significant negative association between right 2D:4D ratio and FT/FE ratio, which was independent of sex. These preliminary findings lend support to an association between low 2D:4D and high levels of FT relative to FE, and high 2D:4D with low FT relative to FE.
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              Pervasive developmental disorders in preschool children: confirmation of high prevalence.

              The rate of reported pervasive developmental disorders has increased, and the authors found a rate of 62.6 per 10,000 in a previous study of preschoolers in Stafford, U.K. They conducted another survey in 2002 to estimate the prevalence in children in a later birth cohort and to compare it to previous findings from the same area. Screening for developmental problems included 10,903 children ages 4.0 to 6.0 years who were living in a Midlands town on the survey date. Children with symptoms suggestive of pervasive developmental disorders were intensively assessed by a multidisciplinary team using standardized diagnostic interviews, psychometric tests, and medical workups. Sixty-four children (85.9% boys) were diagnosed with pervasive developmental disorders. The prevalence was 58.7 per 10,000, with a 95% confidence interval (CI) of 45.2-74.9, for all pervasive developmental disorders, 22.0 per 10,000 (95% CI=14.1-32.7) for autistic disorder, and 36.7 per 10,000 (95% CI=26.2-49.9) for other variants. These rates were not significantly different from the previous rates. The mean age at diagnosis was 37.8 months, and 53.1% of the children were originally referred by health visitors. Of the 64 children with pervasive developmental disorders, 29.8% had mental retardation, but this rate varied by disorder subtype. Few children had associated medical conditions. The rate of pervasive developmental disorders is higher than reported 15 years ago. The rate in this study is comparable to that in previous birth cohorts from the same area and surveyed with the same methods, suggesting a stable incidence.
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                Author and article information

                Journal
                Iran J Psychiatry
                Iran J Psychiatry
                IJPS
                Iranian Journal of Psychiatry
                Tehran University of Medical Sciences
                1735-4587
                2008-2215
                Winter 2012
                : 7
                : 1
                : 41-46
                Affiliations
                [1 ]Department of Psychiatry, Medical University of Silesia in Katowice, ul. Pyskowicka 49, 42-600 Tarnowskie Góry, Poland
                [2 ]Daily Psychiatric Ward for Children, for Children, NZOZ “Feniks”, ul. Młyńska 8, 44-100 Gliwice, Poland
                [3 ]Department of Paediatrics, Paediatric Endocrinology Unit, Medical University of Silesia in Katowice, ul. 3 Maja 13/15, 41-800 Zabrze, Poland
                Author notes
                Corresponding author: Piotr Gorczyca, MD, PhD, Department of Psychiatry, Medical University of Silesia in Katowice, ul. Pyskowicka 49, 42-600 Tarnowskie Góry, Poland, Tel/Fax:0048322854358. E-mail: gormasp@ 123456o2.pl
                Article
                IJPS-7-41
                3395970
                23056117
                0016910a-14d0-45c2-b624-3afc8a85af66
                © 2012 Psychiatry and Psychology Research Center, Tehran University of Medical Sciences

                This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

                History
                Categories
                Original Article

                Clinical Psychology & Psychiatry
                autistic disorder,etiology,asperger syndrome,feature
                Clinical Psychology & Psychiatry
                autistic disorder, etiology, asperger syndrome, feature

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