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      Protein turnover via autophagy: implications for metabolism.

      1 ,
      Annual review of nutrition
      Annual Reviews

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          Abstract

          Autophagy is a process of cellular "self-eating" in which portions of cytoplasm are sequestered within double-membrane cytosolic vesicles termed autophagosomes. The autophagosome cargo is delivered to the lysosome, broken down, and the resulting amino acids recycled after release back into the cytosol. Autophagy occurs in all eukaryotes and can be up-regulated in response to various nutrient limitations. Under these conditions, autophagy may become essential for viability. In addition, autophagy plays a role in certain diseases, acting to prevent some types of neurodegeneration and cancer, and in the elimination of invading pathogens. We review the current information on the mechanism of autophagy, with a focus on its role in protein metabolism and intracellular homeostasis.

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          Author and article information

          Journal
          Annu Rev Nutr
          Annual review of nutrition
          Annual Reviews
          0199-9885
          0199-9885
          2007
          : 27
          Affiliations
          [1 ] Department of Physiology and Cell Biology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. nmizu.phy2@tmd.ac.jp
          Article
          10.1146/annurev.nutr.27.061406.093749
          17311494
          00237a36-f73c-45d2-81a1-98f2e826056f
          History

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