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      Urinary Complement Factor H in Renal Disease


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          Background: Complement factor H (hCFH) plays a key inhibitory role in the control of the alternative complement pathway. We examined whether urinary hCFH (U-hCFH) levels is useful as an indirect indicator of renal damage. Methods: Urine samples were obtained from 104 patients with renal disease. Urine was collected with 10 m M EDTA and U-hCFH levels were measured using the BTA TRAK Assay Kit. Results: In the 62 patients with nephritis, the levels of U-hCFH were elevated (range 15–52,198 U/ml) over the normal range (0–14 U/ml). U-hCFH levels of patients with chronic renal failure, lupus nephritis, membranoproliferative glomerulonephritis, focal glomerulosclerosis were higher than that of IgA nephropathy patients (p < 0.05). In the patients with minimal change disease, showed high levels of U-hCFH during the nephrotic syndrome. U-hCFH was correlated significantly with urinary protein and urinary N-acetyl-β- D-glucosaminidase. Conclusion: We demonstrated that U-hCFH was detected in the urine of nephritis patients.

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          Author and article information

          S. Karger AG
          September 2002
          26 September 2002
          : 92
          : 3
          : 705-707
          Division of Nephrology, Internal Medicine II, Nihon University School of Medicine, Tokyo, Japan
          64090 Nephron 2002;92:705–707
          © 2002 S. Karger AG, Basel

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          : 12 February 2002
          Page count
          Figures: 1, References: 5, Pages: 3
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/64090
          Self URI (text/html): https://www.karger.com/Article/FullText/64090
          Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
          Short Communication

          Cardiovascular Medicine,Nephrology
          Nephritis,Complement activation,Complement factor H,Urine
          Cardiovascular Medicine, Nephrology
          Nephritis, Complement activation, Complement factor H, Urine


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