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      Substance P and Bradykinin Hyperpolarize Pig Coronary Artery Endothelial Cells in Primary Culture


      Journal of Vascular Research

      S. Karger AG

      Endothelial cells, Electrophysiology, Substance P, Bradykinin

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          Substance P (SP) and bradykinin (BK) relax and hyperpolarize smooth muscles of pig coronary arteries in an endothelium-dependent manner. We investigated the effect of both peptides on the membrane potential of endothelial cells in culture. The membrane potential of pig coronary artery endothelial cells in primary culture was -44 mV. SP and BK hyperpolarized it transiently by 23 mV. These hyperpolarizations were dependent on the potassium gradient across the cellular membrane. They had similar time courses as the SP and BK endothelium-dependent hyperpolarizations already observed in smooth muscles.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 26
          : 4
          : 228-234
          Laboratoire de Physiologie Comparee, Departement de Biologie Animale, Universite de Geneve, Suisse
          158770 Blood Vessels 1989;26:228–234
          © 1989 S. Karger AG, Basel

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          Page count
          Pages: 7
          Research Paper


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