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Substance P and Bradykinin Hyperpolarize Pig Coronary Artery Endothelial Cells in Primary Culture
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Abstract
Substance P (SP) and bradykinin (BK) relax and hyperpolarize smooth muscles of pig coronary arteries in an endothelium-dependent manner. We investigated the effect of both peptides on the membrane potential of endothelial cells in culture. The membrane potential of pig coronary artery endothelial cells in primary culture was -44 mV. SP and BK hyperpolarized it transiently by 23 mV. These hyperpolarizations were dependent on the potassium gradient across the cellular membrane. They had similar time courses as the SP and BK endothelium-dependent hyperpolarizations already observed in smooth muscles.
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158770 Blood Vessels 1989;26:228–234Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.