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Cáncer infantil: incidencia y patrones espaciales en la ciudad de Campinas, Brasil, 1996-2005 Translated title: Childhood cancer: incidence and spatial patterns in the city of Campinas, Brazil, 1996-2005

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      Abstract

      RESUMEN Analizamos los patrones espaciales y las incidencias de cáncer en niños, niñas y adolescentes de 0 a 19 años de edad residentes en la ciudad de Campinas, al sureste de Brasil, diagnosticados entre 1996 y 2005. Se clasificaron los cánceres según los grupos de la tercera revisión de la International Classification of Childhood Cancer (ICCC-3). Se incluyeron los cuatro grupos más comunes: leucemias, linfomas, y las neoplasias del sistema nervioso central y de tejidos blandos. Se calcularon tasas de incidencia estandarizadas por edad utilizando la población mundial estándar. Se ajustó un modelo espacial de regresión jerárquica de Bayes (controlando por la heterogeneidad de los datos y la autocorrelación espacial), que asume que el número de casos sigue una distribución de Poisson. Se diagnosticó un total de 180 casos durante el periodo de estudio. La tasa de incidencia bruta para las edades 0-19 años fue de 54,2 por millón y la tasa de incidencia estandarizada por edad fue de 56,5 por millón. Si bien algunas regiones presentan tasas de incidencia más altas al considerar la heterogeneidad y la autocorrelación, no se observaron diferencias estadísticamente significativas en los riesgos relativos.

      Translated abstract

      ABSTRACT This article analyzes cancer incidence and spatial patterns in children and adolescents (0-19 years of age) residing in the city of Campinas in Southeastern Brazil who were diagnosed from 1996-2005. Cancers were classified according to the Third International Classification of Childhood Cancer (ICCC-3) Groups. The four most common groups were studied: leukemias, lymphomas, and central nervous system and soft tissue neoplasms. Age-standardized incidence rates were calculated using the world standard population. A spatial Bayesian hierarchical regression model (controlling for data heterogeneity and spatial autocorrelation) was fitted, assuming that the number of cancer cases follows a Poisson distribution. A total of 180 cases were diagnosed during the study period. Overall, the crude incidence rate was 54.2 per million and the age-standardized incidence rate was 56.5 per million. Although some regions present higher incidence rates, considering the spatial heterogeneity and the spatial autocorrelation, no statistically significant differences in the relative risks were observed.

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      Lei nº 8.080, de 19 de setembro de 1990 - Brasil. Dispõe sobre as condições para a promoção, proteção e recuperação da saúde, a organização e o funcionamento dos serviços correspondentes e dá outras providências

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        Empirical Bayes Estimates of Age-Standardized Relative Risks for Use in Disease Mapping

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          International incidence of childhood cancer, 2001–10: a population-based registry study

          Summary Background Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. Methods This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s. Findings Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years. Interpretation This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research. Funding International Agency for Research on Cancer and the Union for International Cancer Control.
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            Author and article information

            Affiliations
            orgnameUniversidade Estadual de Campinas Brazil djalmore@ 123456unicamp.br
            orgnameUniversidade do Porto orgdiv1Instituto de Ciências Biomédicas Abel Salazar Portugal pnoliveira@ 123456icbas.up.pt
            Chapecó Santa Catarina orgnameUniversidade Federal da Fronteira Sul Brazil jane.friestino@ 123456uffs.edu.br
            orgnameUniversidade do Porto orgdiv1Instituto de Investigação e Inovação em Saúde (i3s) orgdiv2Instituto de Engenharia Biomédica Portugal carlaoliver@ 123456gmail.com
            orgnameUniversidade do Porto orgdiv1Instituto de Ciências Biomédicas Abel Salazar Portugal dvmendon@ 123456icbas.up.pt
            Contributors
            Role: ND
            Role: ND
            Role: ND
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            Journal
            sc
            Salud colectiva
            Salud colect.
            Universidad Nacional de Lanús (Lanús, Buenos Aires, Argentina )
            1669-2381
            1851-8265
            March 2018
            : 14
            : 1
            : 51-63
            S1851-82652018000100051
            10.18294/sc.2018.1200

            This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

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            Product Information: SciELO Public Health

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