Effects of Hydrogen Ion on the Changes in Adenosine Production in the Isolated Rat Heart Perfused at a Constant Flow System

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Abstract

This study was designed to clarify the relationship between the change in H<sup>+</sup> and the nucleoside concentration at a constant coronary flow rate using a Langendorff system. Wistar rat hearts were perfused with Krebs-Henseleit solution (control, pH 7.4) modified to be either acidotic or alkalotic. Coronary perfusion presssure (CPP), left ventricular pressure, and myocardial oxygen consumption were decreased in the acidotic perfusate. On the other hand, these parameters increased in the alkalotic perfusate. Adenosine production in the acidotic perfusate significantly decreased while it significantly increased in the alkalotic perfusate. Furthermore, there was a significant positive correlation between both the percent change in adenosine production and the percent change in CPP in acidosis and alkalosis. It is suggested from these results that the hydrogen ion affects the adenosine metabolism and that the change in coronary blood flow by H<sup>+</sup> is at least partly regulated by adenosine.

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Author and article information

Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1991

Publication date (Print): 1991

Publication date (Electronic): 12 November 2008

Volume: 78

Issue: 2

Pages: 117-123

Affiliations

^aThe Second Department of Internal Medicine, School of Medicine, and ^b School of Nursing and Medical Technology, University of Occupational and Environmental Health Japan, Kitakyushu, Japan

Article

Publisher ID: 174775 Other ID: Cardiology 1991;78:117–123

DOI: 10.1159/000174775

PubMed ID: 2070369

SO-VID: 004a0986-36d3-4e29-8f3f-3a715805b20d

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 05 March 1990

Date accepted : 23 August 1990

Page count

Pages: 7

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