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      Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin.

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          Abstract

          Dapagliflozin, a highly selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycaemia and weight in patients with type 2 diabetes mellitus (T2DM) by increasing urinary glucose excretion. Long-term glycaemic control, body composition and bone safety were evaluated in patients with T2DM after 102 weeks of dapagliflozin treatment.

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          Author and article information

          Journal
          Diabetes Obes Metab
          Diabetes, obesity & metabolism
          1463-1326
          1462-8902
          Feb 2014
          : 16
          : 2
          Affiliations
          [1 ] Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital Huddinge, Karolinska Institute, Stockholm, Sweden.
          Article
          10.1111/dom.12189
          23906445
          004a10f9-e026-4a04-b674-96bbebc15157
          © 2013 John Wiley & Sons Ltd.
          History

          SGLT2 inhibitor,adipose tissue,bone mineral density,fat,metformin,randomized trial,type 2 diabetes

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