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      Personalised Medicine and the Economy of Biotechnological Promise

      research-article
      a , *
      The New Bioethics
      Routledge
      personalised medicine, promissory economy, biotechnology, medical innovation, drug discovery, genomics

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          Abstract

          Rather than seek to distinguish hype from legitimate promise, it may be more helpful to think about personalised medicine as embodying a promissory economy which serves both to mobilize resources for research and — partly at least — to determine the ends to which that research is directed. Personalised medicine is a development of the larger promissory economy of medical biotechnology. As such, it systematically conflates public benefit with the pursuit of commercial and especially pharmaceutical interests. Consequently, research and development in personalised medicine tends to favour the production of expensive new treatments over unprofitable forms of prevention or more effective use of older therapies. A rebalancing of research priorities is needed to favour the pursuit of public benefit, even when it does not deliver private profits. This will in turn require sustained reflection, self-criticism and often self-denial on the part of public research funders and the scientists they support.

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          Most cited references25

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          The myth of the biotech revolution: An assessment of technological, clinical and organisational change

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            Designs on Nature: Science and Democracy in Europe and the United States

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              The drugs don't work: expectations and the shaping of pharmacogenetics.

              This article examines one particular set of technologies arising from developments in human genetics, those aimed at improving the targeting, design and use of conventional small molecule drugs-pharmacogenetics. Much of the debate about the applications and consequences of pharmacogenetics has been highly speculative, since little or no working technology is yet on the market. This article provides a novel analysis of the development of pharmacogenetics, and the social and ethical issues it raises, based on the sociology of technological expectations. In particular, it outlines how two alternative visions for the development of the technology are being articulated and embedded in a range of heterogeneous discourses, artefacts, actor strategies and practices, including: competing scientific research agendas, experimental technologies, emerging industrial structures and new ethical discourses. Expectations of how pharmacogenetics might emerge in each of these arenas are actively shaping the trajectory of this nascent technology and its potential socio-economic consequences.
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                Author and article information

                Journal
                New Bioeth
                New Bioeth
                YNBI
                ynbi20
                The New Bioethics
                Routledge
                2050-2877
                2050-2885
                2 January 2017
                18 May 2017
                : 23
                : 1 , Personalised Medicine: The Promise, the Hype and the Pitfalls
                : 30-37
                Affiliations
                [ a ]Science, Technology and Innovation Studies, University of Edinburgh , Edinburgh, UK
                Author notes
                Correspondence to: Steve Sturdy, STIS, University of Edinburgh , Old Surgeons’ Hall, High School Yards, Edinburgh EH1 1QA, UK. Email: s.sturdy@ 123456ed.ac.uk
                Author information
                http://orcid.org/0000-0002-3273-1727
                Article
                1314892
                10.1080/20502877.2017.1314892
                5448396
                28517983
                004d4297-f651-489b-a842-cf3ebd26d2ce
                © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 27, Pages: 8
                Funding
                Funded by: Wellcome Trust
                Award ID: WT100597MA.
                This work was supported by the Wellcome Trust under grant WT100597MA.
                Categories
                Article
                The Promise and the Hype of ‘Personalised Medicine’

                personalised medicine,promissory economy,biotechnology,medical innovation,drug discovery,genomics

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