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      Urinary Glycosaminoglycans in Different Phases of Balkan Endemic Nephropathy

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          Abstract

          The relationship between glycosaminoglycans and β<sub>2</sub>-microglobulin, glycosaminoglycans and N-acetyl-β- D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in order to establish a method for early detection of this disease. The results show an unquestionable increase in urinary excretion of total glycosaminoglycans in subjects with or suspected of having Balkan endemic nephropathy while the chondroitin sulfate/heparan sulfate ratio was not statistically different between the groups studied. Thus, the chondroitin sulfate/heparan sulfate ratio cannot be used as a cheap and quick semiquantitative method for the diagnosis of early tubular damage in Balkan endemic nephropathy. However, the determination of total glycosaminoglycans in the urine of subjects from endemic areas proved to be valuable additional information helping with the diagnosis of Balkan endemic nephropathy.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1993
          1993
          12 December 2008
          : 65
          : 4
          : 564-567
          Affiliations
          aInstitute for Medical Biochemistry, Faculty of Pharmacy and Biochemistry, University of Zagreb, and bInstitute for Clinical Laboratory Diagnostics, Medical Faculty, University of Zagreb, Clinical Hospital Center Rebro, Zagreb, Croatia
          Article
          187564 Nephron 1993;65:564–567
          10.1159/000187564
          8302410
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 4
          Categories
          Original Paper

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