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      Principles and Methods of Preparation of Platelet-Rich Plasma: A Review and Author's Perspective

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          Abstract

          The utility of platelet-rich plasma (PRP) has spanned various fields of dermatology from chronic ulcer management to trichology and aesthetics, due to its role in wound healing. Though PRP is being used over a long time, there is still confusion over proper terminology to define, classify and describe the different variations of platelet concentrates. There is also a wide variation in the reported protocols for standardization and preparation of PRP, in addition to lack of accurate characterization of the tested products in most articles on the topic. Additionally, the high cost of commercially available PRP kits, precludes its use over a larger population.

          In this article, we review the principles and preparation methods of PRP based on available literature and place our perspective in standardizing a safe, simple protocol that can be followed to obtain an optimal consistent platelet yield.

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          Most cited references43

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          Platelet-rich plasma: evidence to support its use.

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            Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF).

            The topical use of platelet concentrates is recent and its efficiency remains controversial. Several techniques for platelet concentrates are available; however, their applications have been confusing because each method leads to a different product with different biology and potential uses. Here, we present classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content: pure platelet-rich plasma (P-PRP), such as cell separator PRP, Vivostat PRF or Anitua's PRGF; leucocyte- and platelet-rich plasma (L-PRP), such as Curasan, Regen, Plateltex, SmartPReP, PCCS, Magellan or GPS PRP; pure plaletet-rich fibrin (P-PRF), such as Fibrinet; and leucocyte- and platelet-rich fibrin (L-PRF), such as Choukroun's PRF. This classification should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.
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              Platelet-rich plasma (PRP): what is PRP and what is not PRP?

              R Marx (2001)
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                Author and article information

                Journal
                J Cutan Aesthet Surg
                J Cutan Aesthet Surg
                JCAS
                Journal of Cutaneous and Aesthetic Surgery
                Medknow Publications & Media Pvt Ltd (India )
                0974-2077
                0974-5157
                Oct-Dec 2014
                : 7
                : 4
                : 189-197
                Affiliations
                [1]Department of Dermatology, Lokmanya Tilak Municipal (LTM) Medical College and Hospital, Mumbai, Maharashtra, India
                Author notes
                Address for correspondence: Dr. Rachita Dhurat, B 14/2, Maitri Park CHS, Sion, Trombay Road, Chembur, Mumbai - 400 071, Maharashtra, India. E-mail: rachitadhurat@ 123456yahoo.co.in
                Article
                JCAS-7-189
                10.4103/0974-2077.150734
                4338460
                005a9bd0-7151-4d64-bd29-683f901e5f8b
                Copyright: © Journal of Cutaneous and Aesthetic Surgery

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                Categories
                Review Article

                Surgery
                platelet-rich plasma,preparation,principles,standardization
                Surgery
                platelet-rich plasma, preparation, principles, standardization

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