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      Forecasting Future Asthma Hospital Encounters of Patients With Asthma in an Academic Health Care System: Predictive Model Development and Secondary Analysis Study

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          Asthma affects a large proportion of the population and leads to many hospital encounters involving both hospitalizations and emergency department visits every year. To lower the number of such encounters, many health care systems and health plans deploy predictive models to prospectively identify patients at high risk and offer them care management services for preventive care. However, the previous models do not have sufficient accuracy for serving this purpose well. Embracing the modeling strategy of examining many candidate features, we built a new machine learning model to forecast future asthma hospital encounters of patients with asthma at Intermountain Healthcare, a nonacademic health care system. This model is more accurate than the previously published models. However, it is unclear how well our modeling strategy generalizes to academic health care systems, whose patient composition differs from that of Intermountain Healthcare.


          This study aims to evaluate the generalizability of our modeling strategy to the University of Washington Medicine (UWM), an academic health care system.


          All adult patients with asthma who visited UWM facilities between 2011 and 2018 served as the patient cohort. We considered 234 candidate features. Through a secondary analysis of 82,888 UWM data instances from 2011 to 2018, we built a machine learning model to forecast asthma hospital encounters of patients with asthma in the subsequent 12 months.


          Our UWM model yielded an area under the receiver operating characteristic curve (AUC) of 0.902. When placing the cutoff point for making binary classification at the top 10% (1464/14,644) of patients with asthma with the largest forecasted risk, our UWM model yielded an accuracy of 90.6% (13,268/14,644), a sensitivity of 70.2% (153/218), and a specificity of 90.91% (13,115/14,426).


          Our modeling strategy showed excellent generalizability to the UWM, leading to a model with an AUC that is higher than all of the AUCs previously reported in the literature for forecasting asthma hospital encounters. After further optimization, our model could be used to facilitate the efficient and effective allocation of asthma care management resources to improve outcomes.

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            Machine Learning for Outcome Prediction of Acute Ischemic Stroke Post Intra-Arterial Therapy

            Introduction Stroke is a major cause of death and disability. Accurately predicting stroke outcome from a set of predictive variables may identify high-risk patients and guide treatment approaches, leading to decreased morbidity. Logistic regression models allow for the identification and validation of predictive variables. However, advanced machine learning algorithms offer an alternative, in particular, for large-scale multi-institutional data, with the advantage of easily incorporating newly available data to improve prediction performance. Our aim was to design and compare different machine learning methods, capable of predicting the outcome of endovascular intervention in acute anterior circulation ischaemic stroke. Method We conducted a retrospective study of a prospectively collected database of acute ischaemic stroke treated by endovascular intervention. Using SPSS®, MATLAB®, and Rapidminer®, classical statistics as well as artificial neural network and support vector algorithms were applied to design a supervised machine capable of classifying these predictors into potential good and poor outcomes. These algorithms were trained, validated and tested using randomly divided data. Results We included 107 consecutive acute anterior circulation ischaemic stroke patients treated by endovascular technique. Sixty-six were male and the mean age of 65.3. All the available demographic, procedural and clinical factors were included into the models. The final confusion matrix of the neural network, demonstrated an overall congruency of ∼80% between the target and output classes, with favourable receiving operative characteristics. However, after optimisation, the support vector machine had a relatively better performance, with a root mean squared error of 2.064 (SD: ±0.408). Discussion We showed promising accuracy of outcome prediction, using supervised machine learning algorithms, with potential for incorporation of larger multicenter datasets, likely further improving prediction. Finally, we propose that a robust machine learning system can potentially optimise the selection process for endovascular versus medical treatment in the management of acute stroke.
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                Author and article information

                J Med Internet Res
                J Med Internet Res
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                April 2021
                16 April 2021
                : 23
                : 4
                [1 ] Department of Biomedical Informatics and Medical Education University of Washington Seattle, WA United States
                [2 ] The Breathing Institute Department of Pediatrics University of Colorado School of Medicine, Children’s Hospital Colorado Aurora, CO United States
                [3 ] Department of Surgery University of Washington Seattle, WA United States
                [4 ] Department of Health Services University of Washington Seattle, WA United States
                [5 ] Seattle Epidemiologic Research and Information Center & Division of Rehabilitation Care Services VA Puget Sound Health Care System Seattle, WA United States
                [6 ] Clinical Learning, Evidence, and Research (CLEAR) Center University of Washington Seattle, WA United States
                [7 ] Department of Rehabilitation Medicine University of Washington Seattle, WA United States
                Author notes
                Corresponding Author: Gang Luo gangluo@ 123456cs.wisc.edu
                ©Yao Tong, Amanda I Messinger, Adam B Wilcox, Sean D Mooney, Giana H Davidson, Pradeep Suri, Gang Luo. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 16.04.2021.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included.

                Original Paper
                Original Paper


                asthma, forecasting, machine learning, patient care management, risk factors


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